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Literature summary extracted from

  • Xu, M.; Kitaura, Y.; Ishikawa, T.; Kadota, Y.; Terai, C.; Shindo, D.; Morioka, T.; Ota, M.; Morishita, Y.; Ishihara, K.; Shimomura, Y.
    Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism (2017), PLoS ONE, 12, e0180989 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Mus musculus O55028
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 muscle
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 Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
2.7.11.4 BCKA dehydrogenase kinase
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 Mus musculus
2.7.11.4 BDK
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 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.11.4 malfunction the endurance performance enhanced by 2 weeks of running training is somewhat, but significantly less in BDK-mKO mice than in control mice. Skeletal muscle of BDK-mKO mice has low levels of glycogen. Catabolism of branched-chain amino acids (BCAAs) is greatly enhanced in the muscle of BDK-mKO mice and produces branched-chain acyl-carnitine, which induces perturbation of energy metabolism in the muscle Mus musculus